Pathophysiology II Final 2 of 3

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Question 1: Beta amyloid protein is a key constituent of a "feature" found in most Alzheimer's patients:
Nurofibrillary tangles
Tau protein
None of the above
Neuritic plaques
Nutritional deficiencies

Question 2: Neurofibrillary tangles are the most often found in particular areas of the CNS such as the:
Hypothalamus
Some of the above
None of the above
Basal ganglia
Hippocampus

Question 3: Tau protein is a structural support protein for the intracellular structures known as the:
Golgi apparatus
Endoplasmic reticulum (rough)
Microtubules
Mitochondria
None of the above

Question 4: The presence of Alzheimer's dementia is noted in part by decreases in various cognitive abilities such as:
Memory, particularly short-term
Recognition of people/places
Some of the above
All of the above
Vocabulary/words

Question 5: Non-vegetative signs of depression include:
All of the above
Some of the above
Hopelessness
Sadness
Feelings of guilt

Question 6: Exogenous depression can be caused by/is related to:
Some of the above
Mental/emotional/sexual abuse as a child
All of the above
The loss of a close family friend/family member/spouse/child
A major, life-threatening health crisis

Question 7: A bipolar disease "rapid cycler" has cycles that last less than:
30 days
180 days
15 days
90 days
1 year

Question 8: Psychosis is though to be at least partially the result of too much dopaminergic activity at/in the:
None of the above
Cerebellum
Hypothalamus
Cingulate gyrus
Some of the above

Question 9: Which of the following organs/tissues is/are acted upon by PTH but not by calcitonin in the regulation of Ca++ levels?
GI tract
Kidneys
Bone
None of the above
Some of the above

Question 10: In regards to Ca++ regulation, RANK is located in:
Kidney juxtaglomerular cells
None of the above
The anterior pituary cells
Some of the above
GI mucosal cells

Question 11: In what organ does PTH work to convert calcifediol to calcitriol?
Bone
Kidney
GI tract
None of the above
Liver

Question 12: For a person to be diagnosed with "induction insomnia" they need to be consistently not fall asleep within:
20 min
1 hour
10 min
30 min
5 min

Question 13: Historically, the way that we got an insomniac to "sleep" was to increase the activity/influence of:
Central cholinergic nicotinic receptors
Central alpha adrenergic receptors
GABAa receptors
Serotonergic 5-HT1 receptors
None of the above

Question 14: During a "normal" nights sleep, when does the majority of the "REM sleep" occur?
Middle 50%
Within the first 10 minutes after falling asleep
Last 25%
First 25%
REM is evenly distributed throughout the duration of sleep

Question 15: Older hypnotic drugs do not cause a true sleep, but rather a "sleep-like" state (hypnotic). in this state one stage of the normal sleep pattern is lengthened at the expense of all the others. This stage is:
REM
Two
Zero
Four
None of the above

Question 16: BDZ receptors are located upon certain varieties of the receptor for:
Norepinephrine
GABA
Dopamine
Serotonin
Acetylcholine

Question 17: "Powder burn" spots are associated with:
Secondary dysmenorrhea
PCOS
Endometriosis
None of the above
Amenorrhea

Question 18: What features of a female's breast are stimulated to grow/develop by progesterone?
The ductal system
Blood vessels and other supportive structures
Nipple and areolar area
Mammary alveolar tissue/secretory structures
None of the above

Question 19: In which area of the hypothalamus is estrogen a negative feedback inhibitor of LHRH?
Supraoptic nucleus
Some of the above
Arcuate nucleus
Paraventricular nucleus
None of the above

Question 20: A dysfunction of estrogen activity in either of the nuclei mentioned in the previous question could lead to:
None of the above
Endometriosis
Some of the above
Infertility
Increased vaginal secretions

Question 21: What is the major source of estrogen in a non-pregnant female?
None of the above
The adrenal glands
The anterior pituitary
The developing, "Graafian" follicle
The placenta

Question 22: Following ovulation female progesterone levels rise because of increased synthesis/secretion by the:
Stratum granulosum tissue in the corpus luteum
Adrenal reticularis
Glandular cells of the breast
None of the above
The chorion layer of the endometrium

Question 23: Among progesterone's actions is/are:
Some of the above
A thermogenic action
Stimulation of glandular development in the breast
All of the above
Endometrial glandular development

Question 24: Symptoms of endometriosis may include:
Increased body temperature of about 1*F
Abdominal pain, cramping particularly during periods
Some of the above
All of the above
"heavy" uterine bleeding during periods

Question 25: Insulin resistance leading to hyperglycemia is a sign/symptom of:
Pelvic inflammatory disease (PID)
Primary dysmenorrhea
Polycystic ovarian disease
Endometriosis
None of the above

Question 26: A female who is developing PCOS may experience:
Heavier than normal menstrual flow
Weight gain
Hair growth/hirsutism
All of the above
Some of the above

Question 27: Excessive amounts of uterine prostaglandin F is the cause of:
Leiomyomas (fibroids)
Endometriosis
PCOS
Some of the above
None of the above

Question 28: One cause of PID is infection. Among the infectious agents with a strong association to this condition we include:
Syphilis
HPV
None of the above
Some of the above
Chlamydia

Question 29: Inhibition of PDE5 is a possible therapy for:
Primary dysmenorrhea
Varicocele
None of the above
Erectile dysfunction
BPH

Question 30: A lack of fetal androgen causes which embryonic ductal system to deteriorate?
Wolffian
None of the above
Some of the above
Fallopian
Mullerian

Question 31: When we speak of an androgen's "anabolic actions" we include:
All of the above
Skeletal muscle growth and development
Prostatic development
Some of the above
Increased erythropoiesis

Question 32: The most common cause of juvenile testicular failure is:
Varicocele
Kallman's syndrome
None of the above
Orchitis
Cryptorchidism

Question 33: Which bacterium/virus is most commonly associated with orchitis?
Rubella
E. coli
Streptococcus
None of the above
Mumps

Question 34: Target tissues (in males) with dihydrotestosterone specific receptors include:
Skeletal muscle
All of the above
Larynx
Prostate
Some of the above

Question 35: "Chocolate cysts" result from endometrial tissue growing in/on the:
Ovary
Uterine muscle
Cervix/vagina
None of the above
Perotoneal wall

Question 36: Neurogenic bladder can be caused by neuropathies like diabetes mellitus, but more often it is due to:
Kidney stones
None of the above
Stress
Acute infection
CNS lesions

Question 37: An Ag/Ab relation in the kidney is commonly associated with the cause of:
Pyelonephritis
None of the above
Cystitis
Glomerulonephritis
Kidney stones

Question 38: Women are more prone to cystitis because:
The lack prostate antibiotic factor
Estrogen tends to stimulate bacterial flora in/around the lower pelvic region
All of the above
Some of the above
Of their anatomy; ie. a shorter urethra

Question 39: Which secretion(s) of the adrenal gland is/are "pituitary independent"?
Cortisol
Aldosterone
Epinephrine
Some of the above
None of the above

Question 40: The zona reticularis secretes:
Cortisol
Any of the above
None of the above
Aldosterone
Testosterone

Question 41: What adrenal pathology can be caused by an oat cell carcinoma?
Addison's disease
CAH
Conn's syndrome
Cushing's disease
Grave's disease

Question 42: Luckily, the form of CAH that is the most fatal is also the least prevalent. This form results from a loack of:
21-beta hydroxylase
3-beta-hydroxylase
All of the above are equal in prevalence
11-beta-hydroxylase
None of the above is fatal

Question 43: An increase in glucocorticoids whether endogenous or exogenous) will cause an increase in:
Some of the above
Amount/volume of acid secretion
PH
Amount/volume of pepsin secretion
All of the above

Question 44: Which of the following inflammation/repair parameters decreases in a patient with Cushing's Disease?
Some of the above
Number of fibroblasts
All of the above
White cell phagocytic activity
Granulocyte diapedesis activity

Question 45: The two major symptoms that indicate that a patient has Conn's syndrome are:
Hypokalemia/hypotension
Hyperkalemia/hypotension
Hyperkalemia/hypertension
None of the above
Hypokalemia/hypertension

Question 46: "Buffalo hump" is a condition associate with which disease/condition?
Some of the above
Cushing's syndrome
None of the above
Addison's disease
CAH

Question 47: Increased "freckling" and darkening of the skin can be a sign/symptom of:
Conn's syndrome
Cushing's disease
CAH w/ hypertension
Addison's disease
None of the above

Question 48: The testosterone responsible for sperm maturation is mostly secreted by:
all of the above
Leydig cells
Interstitial cells
Sustentacular cells
Some of the above

Question 49: In the male LH is called/named:
MSH
None of the above
FSH
ICSH
LHRH

Question 50: The physiologic process by which oxygen goes from the alveoli to the blood stream is known as:
Ventilation
Perfusion
Respiration
None of the above
Diffusion

Question 51: In addition to its role in the exchange of blood gases into an out of the air, the respiratory system is an important factor in/for:
Maintenance of acid-base equilibrium
Cardiovascular hemodynamics
Some of the above
Systemic inflammation/repair
All of the above

Question 52: Among the causes of respiratory failure, one can include:
An impairment of ventilation
An impairment of diffusion
Some of the above
All of the above
An impairment of the ventilation/perfusion ratio

Question 53: The best hypothesis as to the reason/cause of an acute respiratory distress syndrome (ARDS) in an adult is:
None of the above
Injury to the pulmonary microcirculation
An immunologic reaction
A sudden drop in blood pressur/blood flow in the pulmonary circulation
Depression in the brain stem

Question 54: Whatever the cause, the major problem in ARDS is:
Atelectasis
None of the above
Thromboemboli in the pulmonary circulation
The increase in oxygen concentration in the alveoli
A decrease in elasticity/compliance

Question 55: SIDS is thought to result because of the loss of the major infant drive to respiration which is the:
Neurogenic drive
Hypercapnic drive
Hypoxic drive
Voluntary drive
None of the above

Question 56: What is cor pulmonale?
Pulmonary hypotension
None of the above
Mitral valve collapse
Chest pneumothorax (hole in the thoracic cavity)
Right sided heart failure

Question 57: The three characteristics of asthma include:
Mucosal edema
Bronchiolar hyper-reactivity
All of the above
Increased mucous production
Some of the above

Question 58: For a proper diagnosis of extrinsic asthma, the cause should be a/an:
Emotional stress
Chemical/drug
Antigen (allergy)
None of the above
Pollutant

Question 59: Receiving a "salty kiss" indicates that the other individual may suffer from:
None of the above
Extrinsic asthma
Exercise-induced asthma
Sarcoidosis
Cystic fibrosis

Question 60: Silica dust (or chain silicates) is the causative agent for:
Some of the above
"Black lung" disease in coal miners
Asbestosis
All of the above
Silicosis

t < 1 h

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